Maple 11 (a product that can cost a thousand dollars) wouldn't save! Turns out you have to run it in "Compatiability Mode Windows 2000". Good 20 minutes blown figuring that out. I want money.
How about compatiablity mode: Don't Suck!
edit: Oh it turns out its a Java compatiability problem.
It's Java's compatibility problem. Please check compatibility list and you will find ver 1.5 is not compatible with Vista. The solution is go to download Java v1.6 or newer (v1.6.1 currently), and after installation, go to your drive which has folder "Windows" in it (for example, if your windows is installed in C:\Windows, go to C
, then go to "Program Files" then go to "Java" there's a folder called "bin" and another called "lib", copy both folders to override contents in Maplesoft_folder\jre.